4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid

Base Information

• Chemical Name: 4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid
• CAS No.: 1323432-93-4
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 188.078
• Mol file: 1323432-93-4.mol

Synonyms:4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid

Chemical Property of 4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid

There total 2 articles about 4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dihydrofuran-2,5-dione-2,3,4,5-13C4 (411220-47-8) + benzene-(13)C6 (32488-44-1) → 4-oxo-4-(phenyl-13C6)butanoic-1,2,3,4-13C4 acid (1323432-93-4,1346600-75-6)

Guidance literature:

dihydrofuran-2,5-dione-2,3,4,5-¹³C₄; With sulfuryl dichloride; for 3h; Inert atmosphere; Reflux;

benzene-⁽¹³⁾C₆; With aluminum (III) chloride; In 1,1,2,2-tetrachloroethane; at 25 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c8ob00227d

Reference yield:

(13)C4H5ClO3 + benzene-(13)C6 (32488-44-1) → 4-oxo-4-(phenyl-13C6)butanoic-1,2,3,4-13C4 acid (1323432-93-4,1346600-75-6)

Guidance literature:

With aluminum (III) chloride; In 1,1,2,2-tetrachloroethane; at 20 ℃; Cooling with ice;

DOI:10.1039/c0ob01107j

Reference yield:

4-oxo-4-(phenyl-13C6)butanoic-1,2,3,4-13C4 acid (1323432-93-4,1346600-75-6) → 4-(phenyl-13C6)butanoic-1,2,3,4-13C4 acid (1323432-95-6)

Guidance literature:

4-oxo-4-(phenyl-¹³C₆)butanoic-1,2,3,4-¹³C₄ acid; With hydrazine hydrate; In diethylene glycol; at 20 ℃; for 0.5h;

With potassium hydroxide; In diethylene glycol; at 120 - 215 ℃;

DOI:10.1039/c0ob01107j

upstream raw materials:

dihydrofuran-2,5-dione-2,3,4,5-¹³C₄

benzene-⁽¹³⁾C₆

Downstream raw materials:

U-⁽¹³⁾C-naphthalene

U-(13)C-phenanthrene

U-(13)C-pyrene

U-⁽¹³⁾C-phthalic acid

Refernces

• 1、 Feng, Liwen,Lanfranchi, Don Antoine,Cotos, Leandro,Cesar-Rodo, Elena,Ehrhardt, Katharina,Goetz, Alice-Anne,Zimmermann, Herbert,Fenaille, Fran?ois,Blandin, Stephanie A.,Davioud-Charvet, Elisabeth. "Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation". supporting information. p. 2647 - 2665. Retrieved 2018/04/27.