S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

Base Information

Chemical Name:S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate
CAS No.:1255928-53-0
Molecular Formula:C₂₇H₂₈FNO₃S
Molecular Weight:465.589
Hs Code.:

Synonyms:S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

Chemical Property:

Purity/Quality:

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Technology Process of S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

There total 5 articles about S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-42-6
4-Fluorothiophenol

: 1255928-51-8
(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoic acid

: 1255928-53-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja104999v

Reference yield:

: 1255928-47-2
3-(dimethylamino)-5-(ethoxycarbonyl)benzoic acid

: 1255928-53-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Reflux

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

3.1: triethyl phosphite / 3 h / 150 °C

3.2: 18 h / 0 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

With dmap; N-chloro-succinimide; borane-THF; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1255928-48-3
ethyl 3-(dimethylamino)-5-(hydroxymethyl)benzoate

: 1255928-53-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

2.1: triethyl phosphite / 3 h / 150 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

With dmap; N-chloro-succinimide; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane;