S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

Base Information

Chemical Name:S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate
CAS No.:1284215-30-0
Molecular Formula:C₂₅H₂₄FNO₂S
Molecular Weight:421.535
Hs Code.:

Synonyms:S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

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Chemical Property of S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

Chemical Property:

Purity/Quality:

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Technology Process of S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

There total 6 articles about S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255928-53-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)thiobenzoate

: 1284215-30-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; isopropyl alcohol; Inert atmosphere;
DOI:10.1021/ja104999v

Reference yield:

: 1255928-47-2
3-(dimethylamino)-5-(ethoxycarbonyl)benzoic acid

: 1284215-30-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Reflux

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

3.1: triethyl phosphite / 3 h / 150 °C

3.2: 18 h / 0 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

6.1: hydrogenchloride; water / isopropyl alcohol; tetrahydrofuran

With hydrogenchloride; dmap; N-chloro-succinimide; borane-THF; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 1255928-48-3
ethyl 3-(dimethylamino)-5-(hydroxymethyl)benzoate

: 1284215-30-0
S-4-fluorophenyl (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)thiobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

2.1: triethyl phosphite / 3 h / 150 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 °C

5.1: hydrogenchloride; water / isopropyl alcohol; tetrahydrofuran

With hydrogenchloride; dmap; N-chloro-succinimide; water; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;