4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine

Base Information

• Chemical Name: 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine
• CAS No.: 1026320-91-1
• Molecular Formula: C₂₄H₃₀F₂N₂O₂
• Molecular Weight: 416.511

Synonyms:4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine

Chemical Property of 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine

Chemical Property:

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Technology Process of 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine

There total 3 articles about 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-2-methylpiperazine (109-07-9) → 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine (1026320-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / ethanol / 24 h / Heating

2: K₂CO₃, KI / acetonitrile / 24 h / Heating

With sodium hydrogencarbonate; potassium carbonate; potassium iodide; In ethanol; acetonitrile;

DOI:10.1021/jm950894b

Reference yield:

1-chloromethyl-4-fluorobenzene (352-11-4) → 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine (1026320-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / ethanol / 24 h / Heating

2: K₂CO₃, KI / acetonitrile / 24 h / Heating

With sodium hydrogencarbonate; potassium carbonate; potassium iodide; In ethanol; acetonitrile;

DOI:10.1021/jm950894b

Reference yield:

(±)-1-(4-fluorobenzyl)-3-methylpiperazine (178624-87-8) + 4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane (3308-94-9) → 4-(4-Fluoro-benzyl)-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine (1026320-91-1)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 24h; Heating;

DOI:10.1021/jm950894b

upstream raw materials:

(±)-1-(4-fluorobenzyl)-3-methylpiperazine

4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane

(RS)-2-methylpiperazine

1-chloromethyl-4-fluorobenzene

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