toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester
• CAS No.: 1190630-73-9
• Molecular Formula: C₂₂H₂₇N₃O₅S
• Molecular Weight: 445.539

Synonyms:toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester

Chemical Property of toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester

Chemical Property:

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Technology Process of toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester

There total 3 articles about toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester (1190630-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 24 h / 0 - 20 °C

2: pyridinium p-toluenesulfonate / dichloromethane / 24 h

With pyridinium p-toluenesulfonate; In pyridine; dichloromethane;

DOI:10.1021/ml300197h

Reference yield:

(2S,3S)-2-azido-1-phenyl-butane-3,4-diol (116949-67-8) → toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester (1190630-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 24 h / 0 - 20 °C

2: pyridinium p-toluenesulfonate / dichloromethane / 24 h

With pyridinium p-toluenesulfonate; In pyridine; dichloromethane;

DOI:10.1021/ml300197h

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + 3(S)-azido-4-phenyl-1-(p-toluenesulphonyloxy)-2(S)-butanol (136465-96-8) → toluene-4-sulfonic acid 3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl ester (1190630-73-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; for 24h;

DOI:10.1021/ml300197h

upstream raw materials:

p-toluenesulfonyl chloride

3,4-dihydro-2H-pyran

3(S)-azido-4-phenyl-1-(p-toluenesulphonyloxy)-2(S)-butanol

(2S,3S)-2-azido-1-phenyl-butane-3,4-diol

Downstream raw materials:

[(2R,3S)-3-azido-4-phenyl-2-(tetrahydropyran-2-yloxy)butyl]benzylamine

(2R,3S)-3-amino-2-tetrahydropyranyloxy-4-phenyl-1-benzylaminobutane

(2R,3S)-3-Cbz-amino-2-hydroxy-4-phenyl-1-benzylaminobutane

[(1S,2R)-1-benzyl-3-benzylamino-2-(tetrahydropyran-2-yloxy)propyl]carbamic acid benzyl ester

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