5-methoxy-1-methyl-3,4-diphenylisoquinoline

Base Information

• Chemical Name: 5-methoxy-1-methyl-3,4-diphenylisoquinoline
• CAS No.: 1257846-41-5
• Molecular Formula: C₂₃H₁₉NO
• Molecular Weight: 325.41
• Mol file: 1257846-41-5.mol

Synonyms:5-methoxy-1-methyl-3,4-diphenylisoquinoline

Chemical Property of 5-methoxy-1-methyl-3,4-diphenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-methoxy-1-methyl-3,4-diphenylisoquinoline

There total 10 articles about 5-methoxy-1-methyl-3,4-diphenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

C11H14N2O (1536277-73-2) + diphenyl acetylene (501-65-5) → 1-methyl-7-methoxy-3,4-diphenylisoquinoline (1198575-40-4) + 5-methoxy-1-methyl-3,4-diphenylisoquinoline (1257846-41-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In ethanol; at 80 ℃; for 12h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo402497v

Reference yield: 58.0%

(E)-1-(3-methoxyphenyl) ethanone O-acetyl oxime (1257846-26-6) + diphenyl acetylene (501-65-5) → 1-methyl-7-methoxy-3,4-diphenylisoquinoline (1198575-40-4) + 5-methoxy-1-methyl-3,4-diphenylisoquinoline (1257846-41-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; In methanol; at 60 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol102504b

Reference yield: 53.0%

diphenyl acetylene (501-65-5) + 1-(3-Methoxyphenyl)ethanone (586-37-8) → 1-methyl-7-methoxy-3,4-diphenylisoquinoline (1198575-40-4) + 5-methoxy-1-methyl-3,4-diphenylisoquinoline (1257846-41-5)

Guidance literature:

With [RhCp*(CH₃CN)₃] (SbF₆)₂; hydroxylamine-O-sulfonic acid; In methanol; at 70 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201901825

upstream raw materials:

(E)-1-(3-methoxyphenyl) ethanone O-acetyl oxime

diphenyl acetylene

1-(3-Methoxyphenyl)ethanone

C₁₁H₁₄N₂O