2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

Base Information

Chemical Name:2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate
CAS No.:910814-45-8
Molecular Formula:C₂₅H₃₂O₅S₂
Molecular Weight:476.658
Hs Code.:

2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

Synonyms:2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

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Chemical Property of 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

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Technology Process of 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

There total 12 articles about 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875012-70-7
3-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-1-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propan-1-one

: 124-63-0
methanesulfonyl chloride

: 910814-45-8
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 875012-70-7
3-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-1-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propan-1-one

: aq. citric acid

: 124-63-0
methanesulfonyl chloride

: 910814-45-8
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

Guidance literature:: With DIPEA; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: 498-15-7,19079-29-9
(+)-Δ³-carene

: 910814-45-8
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 11 steps

1.1: ozone / methanol / -65 °C

1.2: 2 h / 20 - 35 °C

2.1: thionyl chloride / 0.5 h / 0 °C

3.1: sodium methylate / methanol / 1 h / Reflux

4.1: triphenylphosphine; tetrachloromethane / tetrachloromethane / 65 °C

5.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

5.2: 1 h / 20 °C

5.3: 1 h / 75 °C

6.1: lithium hydroxide; water / ethanol / 2 h / 75 °C

7.1: diethyl ether / 35 °C

8.1: hydrogenchloride / ethanol; isopropyl alcohol / 20 h / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C / 1125.11 Torr

10.1: sodium hydroxide; sodium iodide / water; isopropyl alcohol / 24 h / 65 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With hydrogenchloride; tetrachloromethane; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; sodium methylate; sodium ethanolate; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; isopropyl alcohol; 3.1: |Dieckmann Condensation;
DOI:10.1021/jm4014373