(3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

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Chemical Name:(3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol
CAS No.:127980-31-8
Molecular Formula:C₂₄H₄₀O₄Si
Molecular Weight:420.665
Hs Code.:

Synonyms:(3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

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Chemical Property of (3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

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Technology Process of (3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

There total 3 articles about (3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 127980-31-8
(3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: borane / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h

2: 4-dimethylaminopyridine, triethylamine / CH₂Cl₂ / 30 h / 25 °C

3: 1.) tert-butyllithium / 1.) ether, pentane, a) -100 deg C, 15 min, b) 0 deg C, 15 min, 2.) ether, pentane, THF, 0 deg C, 1 h

With dmap; borane; tert.-butyl lithium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00113a030

Reference yield:

: 28229-69-8
2-(3-bromophenyl)ethan-1-ol

: 127980-31-8
(3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 4-dimethylaminopyridine, triethylamine / CH₂Cl₂ / 30 h / 25 °C

2: 1.) tert-butyllithium / 1.) ether, pentane, a) -100 deg C, 15 min, b) 0 deg C, 15 min, 2.) ether, pentane, THF, 0 deg C, 1 h

With dmap; tert.-butyl lithium; triethylamine; In dichloromethane;
DOI:10.1021/jm00113a030

Reference yield:

: 404575-34-4
7-oxabicyclo<2.2.1>heptane tetrahydrofuranol

: 127980-30-7
<2-(3-bromophenyl)ethoxy>dimethyl(1,1,2-trimethylpropyl)silane

: 127980-31-8
(3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

Guidance literature:: With tert.-butyl lithium; Multistep reaction; 1.) ether, pentane, a) -100 deg C, 15 min, b) 0 deg C, 15 min, 2.) ether, pentane, THF, 0 deg C, 1 h;
DOI:10.1021/jm00113a030