N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]-4-fluorobenzenesulfonamide
CAS No.:263842-54-2
Molecular Formula:C₃₃H₃₈FNO₆S₂
Molecular Weight:627.798
Hs Code.:

N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]-4-fluorobenzenesulfonamide

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Chemical Property of N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]-4-fluorobenzenesulfonamide

Chemical Property:

Vapor Pressure:1.72E-20mmHg at 25°C
Boiling Point:698.7°Cat760mmHg
Flash Point:376.3°C
Density:1.33g/cm³

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Technology Process of N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]-4-fluorobenzenesulfonamide

There total 4 articles about N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 207736-87-6
4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

: 263843-10-3
toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(4-fluorobenzenesulfonylamino)-5-methyl-phenyl] ester

: 263842-54-2
N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-4-fluoro-benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm990281p

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 263842-54-2
N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-4-fluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridine / CH₂Cl₂ / 20 °C

2: 66 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Sulfonylation / 2: Substitution;
DOI:10.1021/jm990281p

Reference yield:

: 66422-87-5
1-(4-hydroxyphenyl)-4-methylpentan-3-one

: 263842-54-2
N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-4-fluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

2: 66 percent / K₂CO₃ / dimethylformamide / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; 2: Substitution;
DOI:10.1021/jm990281p