1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

Base Information

Chemical Name:1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide
CAS No.:867308-86-9
Molecular Formula:C₃₄H₄₄FN₃O₅
Molecular Weight:593.739
Hs Code.:

1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

Synonyms:1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

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Chemical Property of 1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

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Technology Process of 1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

There total 8 articles about 1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 867304-09-4
1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

: 100-46-9
benzylamine

: 867308-86-9
1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/op800092e

Reference yield:

: 867309-02-2
N-(1-benzylcarbamoyl-3-methyl-2-oxobutyl)-4-fluorobenzamide

: 125971-86-0,125995-13-3
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 867308-86-9
1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

Guidance literature:: With benzoic acid; In n-heptane; at 99 ℃; for 14h;

Reference yield:

: 867308-78-9
2-(4-fluorobenzoylamino)-4-methyl-3-oxopentanoic acid benzyl ester

: 867308-86-9
1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 25 °C

3: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; 1,1'-carbonyldiimidazole; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.11.103