1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

Base Information

Chemical Name:1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid
CAS No.:867304-09-4
Molecular Formula:C₂₇H₃₇FN₂O₆
Molecular Weight:504.599
Hs Code.:

Synonyms:1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

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Chemical Property of 1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

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Technology Process of 1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

There total 5 articles about 1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 867308-77-8
1-[2-((4R,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid benzyl ester

: 867304-09-4
1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

Guidance literature:: With hydrogen; palladium on carbon; In tetrahydrofuran;

Reference yield:

: 1319747-40-4
C₂₆H₂₅NO₃

: 867304-09-4
1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: toluene-4-sulfonic acid; acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 25 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;
DOI:10.1016/j.bmcl.2010.11.103

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 867304-09-4
1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl[1,3]dioxan-4-yl)-ethyl]-2-(4-fluoro-phenyl)-5-isopropyl-1H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dichloromethane; water / -10 - 5 °C / Inert atmosphere

1.2: 0.5 h / 0 - 5 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Inert atmosphere; Reflux

3.1: palladium on activated charcoal; hydrogen / 4 h / 25 °C / 2585.81 Torr

With palladium on activated charcoal; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water;
DOI:10.1021/op800092e