(E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

Base Information

Chemical Name:(E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide
CAS No.:99560-33-5
Molecular Formula:C₁₈H₁₉ClF₃N₃O₂S
Molecular Weight:433.882
Hs Code.:

Synonyms:(E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

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Chemical Property of (E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

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Technology Process of (E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

There total 4 articles about (E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99560-38-0
(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propenal

: 99560-33-5
(E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / NaBH₄ / methanol / 3 h / 0 - 5 °C

2: 98 percent / Na₂CO₃ / diethyl ether / 0.5 h

3: buffer / methanol / 1 h / Ambient temperature; pH 10

4: 65 percent / p-TsCl, 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 1.) MeONa / 1.) MeOH, 5 min, 2.) MeOH, 22 h

With dmap; sodium tetrahydroborate; sodium methylate; sodium carbonate; triethylamine; p-toluenesulfonyl chloride; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00350a098

Reference yield:

: 99560-26-6
(E)-3-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-methyl-2-propen-1-ol

: 99560-33-5
(E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Na₂CO₃ / diethyl ether / 0.5 h

2: buffer / methanol / 1 h / Ambient temperature; pH 10

3: 65 percent / p-TsCl, 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) MeONa / 1.) MeOH, 5 min, 2.) MeOH, 22 h

With dmap; sodium methylate; sodium carbonate; triethylamine; p-toluenesulfonyl chloride; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00350a098

Reference yield:

: 99560-29-9
(E)-N-<2-chloro-5-(3-hydroxy-2-methyl-1-propenyl)-3-methoxyphenyl>-2,2,2-trifluoro-N-methylacetamide

: 99560-33-5
(E)-N-<2-chloro-3-methoxy-5-<2-methyl-3-<(1-methyl-1H-imidazol-2-yl)thio>-1-propenyl>phenyl>-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / p-TsCl, 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) MeONa / 1.) MeOH, 5 min, 2.) MeOH, 22 h

With dmap; sodium methylate; triethylamine; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1021/jo00350a098