5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

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Chemical Name:5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid
CAS No.:1403680-11-4
Molecular Formula:C₁₆H₁₀ClF₃N₄O₂
Molecular Weight:382.729
Hs Code.:

Synonyms:5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

There total 5 articles about 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1403679-95-7
ethyl5-(2-aminopyrimidin-4-yI)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

: 1403680-11-4
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

Guidance literature:: ethyl5-(2-aminopyrimidin-4-yI)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate; With ethanol; potassium hydroxide; for 20h; Reflux;

With hydrogenchloride; In water; at 5 ℃;

Reference yield:

: ethyl 5-(2-aminopyrimidin-4-yl)-2-bromo-1H-pyrrole-3-carboxylate

: 1403680-11-4
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; lithium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 5 h / 100 °C

2.1: potassium hydroxide; ethanol / 20 h / Reflux

2.2: 5 °C

With ethanol; sodium carbonate; lithium chloride; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; toluene;

Reference yield:

: 182344-18-9
2-chloro-5-(trifluoromethyl)phenylboronic acid

: 1403680-11-4
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; lithium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 5 h / 100 °C

2.1: potassium hydroxide; ethanol / 20 h / Reflux

2.2: 5 °C

With ethanol; sodium carbonate; lithium chloride; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; toluene;