5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
CAS No.:1403679-33-3
Molecular Formula:C₁₆H₁₁ClF₃N₅O
Molecular Weight:381.744
Hs Code.:

Synonyms:5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

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Chemical Property of 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

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Technology Process of 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

There total 11 articles about 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1403680-25-0
5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

: 1403679-33-3
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: 5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile; With sulfuric acid; trifluoroacetic acid; In water; at 70 ℃; for 8h;

With ammonia; In water; pH=10 - 12;

Reference yield: 82.0%

: 1403680-11-4
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid

: 1403679-33-3
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃;

With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: ethyl 5-(2-aminopyrimidin-4-yl)-2-bromo-1H-pyrrole-3-carboxylate

: 1403679-33-3
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; lithium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 5 h / 100 °C

2.1: potassium hydroxide; ethanol / 20 h / Reflux

2.2: 5 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 °C

3.2: 3 h / 20 °C

With ethanol; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; N,N-dimethyl-formamide; toluene;