5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Base Information

Chemical Name:5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine
CAS No.:615580-31-9
Molecular Formula:C₁₆H₂₅NO₂
Molecular Weight:263.38
Hs Code.:

Synonyms:5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Suppliers and Price of 5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

There total 7 articles about 5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 7-methyl-2-phenyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-3H,4H-2λ⁴-benzo[c][1,2]thiazine 2-oxide

: 615580-31-9
5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Guidance literature:: With amalgam; sodium; In tetrahydrofuran; methanol; at 20 ℃; for 12h;
DOI:10.1016/S0040-4039(03)01882-3

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 615580-31-9
5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / TsOH / 1 h / 0 °C

2: 85 percent / sodium/amalgam / methanol; tetrahydrofuran / 12 h / 20 °C

With amalgam; sodium; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(03)01882-3

Reference yield:

: 66192-28-7
methyl (E)-3-(2-bromo-4-methylphenyl)acrylate

: 615580-31-9
5-Methyl-2-[(S)-1-methyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-phenylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: Pd(OAc)2

1.2: 87 percent / rac-BINAP; Cs₂CO₃ / toluene / 44 h / 110 °C

2.1: 83 percent / LDA / tetrahydrofuran / 1 h / -78 °C

3.1: 89 percent / LAH / tetrahydrofuran / 1 h / 0 °C

4.1: 98 percent / TsOH / 1 h / 0 °C

5.1: 85 percent / sodium/amalgam / methanol; tetrahydrofuran / 12 h / 20 °C

With palladium diacetate; lithium aluminium tetrahydride; amalgam; sodium; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; 2.1: Michael addition reaction;
DOI:10.1016/S0040-4039(03)01882-3