(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester

Base Information

Chemical Name:(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester
CAS No.:223259-26-5
Molecular Formula:C₄₁H₇₈O₄Si₂
Molecular Weight:691.239
Hs Code.:
Mol file:223259-26-5.mol

(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester

Synonyms:(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid 2-triisopropylsilanyloxy-1-triisopropylsilanyloxymethyl-ethyl ester

Suppliers and Price of (5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Medical Isotopes, Inc.
(5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoicAcid1-[[[Tris(1-methylethyl)silyl]oxy]methyl]ethylEster
5 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of (5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester

Chemical Property:

Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:Chlorofrom (Slightly), Methanol (Slightly)

Purity/Quality:: (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoicAcid1-[[[Tris(1-methylethyl)silyl]oxy]methyl]ethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (5Z,8Z,11Z,14Z)-2-[[Tris(1-methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-methylethyl)silyl]oxy]methyl]ethyl Ester is an intermediate in the synthesis of 2-Arachidonoylglycerol (A765050), an major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors.

Technology Process of (5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester

There total 2 articles about (5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 98264-26-7
1,3-Bis-triisopropylsilanyloxy-propan-2-ol

: 223259-26-5
(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid 2-triisopropylsilanyloxy-1-triisopropylsilanyloxymethyl-ethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/S0040-4039(99)00028-3

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 223259-26-5
(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid 2-triisopropylsilanyloxy-1-triisopropylsilanyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / Ambient temperature

2: 94 percent / dimethylaminopyridine, 1-(3-dimethyl-aminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)00028-3

Reference yield: 59.0%

: 223259-26-5
(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid 2-triisopropylsilanyloxy-1-triisopropylsilanyloxymethyl-ethyl ester

: 53847-30-6
2-arachidonoyl glycerol

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; -25 deg C, overnight then r.t., 1 h;
DOI:10.1016/S0040-4039(99)00028-3