4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine

Base Information

• Chemical Name: 4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine
• CAS No.: 1181214-67-4
• Molecular Formula: C₁₈H₉F₆N₃O₂
• Molecular Weight: 413.279
• Mol file: 1181214-67-4.mol

Synonyms:4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine

Chemical Property of 4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine

There total 2 articles about 4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(trifluoromethyl)benzimidamide hydrochloride (38980-96-0) + C10H5BrF3NO3 → 4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine (1181214-67-4)

Guidance literature:

4-(trifluoromethyl)benzimidamide hydrochloride; With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 40 ℃; for 0.5h; Inert atmosphere;

C₁₀H₅BrF₃NO₃; In acetonitrile; for 3h; Inert atmosphere; Reflux;

DOI:10.1055/s-0040-1707969

Reference yield: 41.0%

4-trifluoromethyl-2-methylsulfanyl-6-(4-nitrophenyl)-pyrimidine (1181214-68-5) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine (1181214-67-4)

Guidance literature:

With trifuran-2-yl-phosphane; copper(II) thiophene-2-carboxylate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; at 50 - 52 ℃; for 15h;

Reference yield:

4-(4-nitrophenyl)-6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrimidine (1181214-67-4) → 4-trifluoromethyl-6-(4-aminophenyl)-2-(4-trifluoromethyl-phenyl)-pyrimidine (1181214-66-3)

Guidance literature:

With ammonium ferric sulfate; iron; In ethanol; water; for 3h; Heating;

upstream raw materials:

4-trifluoromethyl-2-methylsulfanyl-6-(4-nitrophenyl)-pyrimidine

4-trifluoromethylphenylboronic acid

4-(trifluoromethyl)benzimidamide hydrochloride

Downstream raw materials:

4-trifluoromethyl-6-(4-aminophenyl)-2-(4-trifluoromethyl-phenyl)-pyrimidine