{(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate

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Chemical Name:{(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate
CAS No.:1135150-53-6
Molecular Formula:C₃₃H₃₃F₆NO₆
Molecular Weight:653.619
Hs Code.:

Synonyms:{(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate

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Chemical Property of {(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate

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Technology Process of {(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate

There total 5 articles about {(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1135150-45-6
cis-1-benzyl-3-(hydroxymethyl)piperidin-4-ol

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 1135150-53-6
{(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/hlca.200800270

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1135150-53-6
{(3R,4R)-1-benzyl-4-[(2R)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αR)-α-methoxy-α-(trifluoromethyl)-benzeneacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; sodium carbonate / isopropyl alcohol / 10 °C

1.2: 20 °C

2.1: toluene-4-sulfonic acid / dichloromethane

3.1: Chiralcel_.(R). OD / ethanol; hexane / Resolution of racemate

4.1: dmap; triethylamine / dichloromethane / 20 °C

With dmap; sodium tetrahydroborate; sodium carbonate; toluene-4-sulfonic acid; triethylamine; In ethanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1002/hlca.201100369