41276-30-6Relevant articles and documents
Synthesis and Stereochemistry of Some 3-Azabicyclo[3.3.1]nonane Derivatives
Vafina,Yakhina,Khakimova,Spirikhin,Galin,Yunusov
, p. 49 - 56 (2003)
Michael reactions of methyl (ethyl) 1-benzyl-4-oxopiperidine-3- carboxylates with a number of α,β-unsaturated carbonyl compounds result in formation of 6- and 6,8-substituted methyl (ethyl) 3-benzyl-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylates. Stereochemical aspects of these reactions were studied, and some further transformations of the products were performed.
AZA-DIHYDRO-ACRIDONE DERIVATIVES
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Paragraph 0245; 0246, (2018/10/19)
Aza-dihydro-acridone derivatives of formula I, wherein the meaning of R1, R'1, R2 and R3 is that specified in the description, to be used as T cells proliferation inhibitors.
New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones
Szántó, Gábor,Makó, Attila,Vágó, István,Hergert, Tamás,Bata, Imre,Farkas, Bence,Kolok, Sándor,Vastag, Mónika
, p. 3905 - 3912 (2016/08/01)
Numerous potent P2X3 antagonists have been discovered and the therapeutic potential of P2X3 antagonism already comprises proof-of-concept data obtained in clinical trials with the most advanced compound. We have lately reported the discovery and optimization of thia-triaza-tricycle compounds with potent P2X3 antagonistic properties. This Letter describes the SAR of a back-up series containing a 4-oxo-quinazoline central ring. The discovery of the highly potent compounds 51 is presented.