ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

Base Information

Chemical Name:ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate
CAS No.:1235477-28-7
Molecular Formula:C₂₆H₂₇N₃O₆
Molecular Weight:477.517
Hs Code.:

Synonyms:ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

Suppliers and Price of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

There total 6 articles about ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1235477-26-5
2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)acetic acid

: 3081-24-1
H-Phe-OEt

: 1235477-28-7
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1007/s00706-010-0280-x

Reference yield: 62.0%

: 1235477-27-6
2,5-dioxo-1-pyrrolidinyl 2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)acetate

: 3081-24-1
H-Phe-OEt

: 1235477-28-7
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

Guidance literature:: In tetrahydrofuran; for 7h; Reflux;
DOI:10.1007/s00706-010-0280-x

Reference yield:

: 1215293-89-2
3-benzyl-4-imino-2-oxo-1,2,3,4-tetrahydro-5-acetylpyrimidine

: 1235477-28-7
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-phenylpropionate

Guidance literature:: Multi-step reaction with 5 steps

1: water; acetic acid / 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 50 °C

4: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 0 - 5 °C

5: tetrahydrofuran / 7 h / Reflux

With water; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00706-010-0280-x