tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

Base Information

Chemical Name:tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate
CAS No.:808736-65-4
Molecular Formula:C₂₄H₃₁ClN₆O₄
Molecular Weight:503.001
Hs Code.:

Synonyms:tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

There total 4 articles about tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 808736-62-1
dimethyl 2-bromo-1-(2-chlorobenzyl)-1H-imidazole-4,5-dicarboxylate

: 808736-65-4
tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 0.67 h / Heating / reflux

2: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / DMF (N,N-dimethyl-formamide) / 14 h / 20 °C

3: potassium carbonate / dimethyl sulfoxide / 5 h / 100 °C

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In DMF (N,N-dimethyl-formamide); ethanol; dimethyl sulfoxide;

Reference yield:

: 808736-63-2
2-bromo-1-(2-chlorobenzyl)-1H-imidazole-4,5-dicarboxylic acid

: 808736-65-4
tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / DMF (N,N-dimethyl-formamide) / 14 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 5 h / 100 °C

With 1-hydroxy-7-aza-benzotriazole; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In DMF (N,N-dimethyl-formamide); dimethyl sulfoxide;

Reference yield:

: 705280-65-5
dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate

: 808736-65-4
tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 4 h / 20 °C

2: sodium hydroxide; water / ethanol / 0.67 h / Heating / reflux

3: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / DMF (N,N-dimethyl-formamide) / 14 h / 20 °C

4: potassium carbonate / dimethyl sulfoxide / 5 h / 100 °C

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); ethanol; dimethyl sulfoxide;