808736-62-1

Upstream product

• 705280-65-5 dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 3304-70-9 dimethyl imidazole-4,5-dicarboxylate 

Downstream Products

• 808736-65-4 tert-butyl (3S)-1-[1-(2-chlorobenzyl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]-3-piperidinylcarbamate 
• 808736-63-2 2-bromo-1-(2-chlorobenzyl)-1H-imidazole-4,5-dicarboxylic acid 

Relevant academic research and scientific papers

Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration

Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accomplished.

1H-IMIDAZO`4,5-D!PYRIDAZINES AS DPP-IV INHIBITORS FOR THE TREATMENT OF NIDDM

A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X and Y each is independently O, etc.; R1 and R2 each is independently H or (lower)alkyl; R3 is (lower)alkenyl, etc; R4 and R5 each is independently H or (lower)alkyl; n