(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane
CAS No.:1147324-89-7
Molecular Formula:C₄₁H₄₂N₂O₁₀S
Molecular Weight:754.858
Hs Code.:

Synonyms:(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

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Chemical Property of (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

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Technology Process of (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

There total 1 articles about (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₄N₂O₈S

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1147324-89-7
(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jo900391n

Reference yield: 89.0%

: 1147324-89-7
(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

: 276679-09-5
diisopropyl-phosphoramidous acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-cyano-ethyl ester

: 1147324-92-2
(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

Guidance literature:: (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane; diisopropyl-phosphoramidous acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-cyano-ethyl ester; With 5-(ethylthio)-1H-tetrazole; In acetonitrile; at 20 ℃; for 4h;

With pyridine; iodine; In tetrahydrofuran; water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo900391n