(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

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Chemical Name:(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane
CAS No.:1147324-92-2
Molecular Formula:C₆₀H₇₂N₅O₁₇PSSi
Molecular Weight:1226.38
Hs Code.:

(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

Synonyms:(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

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Chemical Property of (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

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Technology Process of (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

There total 1 articles about (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1147324-89-7
(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

: 276679-09-5
diisopropyl-phosphoramidous acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-cyano-ethyl ester

: 1147324-92-2
(1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-(cyanoethyl 5'-O-(3'-O-tert-butyldimethylsilyl)thymidinyl phosphate)-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane

Guidance literature:: (1R,3R,4R,5S,6S,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-6-tosylate-3-(thymin-1-yl)-2-oxabicyclo[2.2.1]heptane; diisopropyl-phosphoramidous acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-cyano-ethyl ester; With 5-(ethylthio)-1H-tetrazole; In acetonitrile; at 20 ℃; for 4h;

With pyridine; iodine; In tetrahydrofuran; water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo900391n