1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate
• CAS No.: 122948-56-5
• Molecular Formula: C₁₃H₁₃F₃O₃S
• Molecular Weight: 306.306
• Mol file: 122948-56-5.mol

Synonyms:1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate

Chemical Property of 1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate

There total 1 articles about 1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(RS)-2-phenylcyclohexanone (1444-65-1) + N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide (145100-51-2) → 1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate (122948-56-5)

Guidance literature:

(RS)-2-phenylcyclohexanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00845

Reference yield: 79.0%

1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate (122948-56-5) → 4-oxo-1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate

Guidance literature:

With tert.-butylhydroperoxide; iron(III) chloride; In water; acetonitrile; at 40 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.9b00845

Reference yield:

trimethylsilylmethyllithium (1822-00-0) + 1,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl trifluoromethanesulfonate (122948-56-5) → Trimethyl-(6-phenyl-cyclohex-1-enylmethyl)-silane (122948-50-9)

Guidance literature:

With aluminium trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Yield given. Multistep reaction; 1.) pentane, 1,2-dichloroethane; room temp., 2.) benzene, 23 deg C, 1 h;

DOI:10.1021/ja00203a066

upstream raw materials:

(RS)-2-phenylcyclohexanone

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

Downstream raw materials:

Trimethyl-(6-phenyl-cyclohex-1-enylmethyl)-silane