3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

Base Information

• Chemical Name: 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid
• CAS No.: 1026603-37-1
• Molecular Formula: C₂₁H₃₀NO₄P
• Molecular Weight: 391.447
• Mol file: 1026603-37-1.mol

Synonyms:3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

Chemical Property of 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

There total 5 articles about 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-propionic acid (182193-41-5) → 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid (1026603-37-1)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 0.2h; Ambient temperature;

DOI:10.1021/jo9603439

Reference yield:

1-Adamantyl bromide (768-90-1) → 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid (1026603-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Ag₂O / CHCl₃ / 1.33 h / Heating

2: 86 percent / 4 N NaOH / ethanol / 2 h

3: ammonium formate / Pd/C / methanol / 0.2 h / Ambient temperature

With sodium hydroxide; ammonium formate; silver(l) oxide; palladium on activated charcoal; In methanol; ethanol; chloroform;

DOI:10.1021/jo9603439

Reference yield:

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid (115961-49-4) → 3-[(Adamantan-1-yloxy)-(1-amino-2-phenyl-ethyl)-phosphinoyl]-propionic acid (1026603-37-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) hexamethyldisilazane / 1) 110 deg C, 1 h, 2) 90 deg C, 4 h

2: Ag₂O / CHCl₃ / 1.33 h / Heating

3: 86 percent / 4 N NaOH / ethanol / 2 h

4: ammonium formate / Pd/C / methanol / 0.2 h / Ambient temperature

With sodium hydroxide; ammonium formate; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; palladium on activated charcoal; In methanol; ethanol; chloroform;

DOI:10.1021/jo9603439

upstream raw materials:

3-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoyl]-propionic acid

1-Adamantyl bromide

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester