3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

Base Information

Chemical Name:3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate
CAS No.:1582262-10-9
Molecular Formula:C₁₉H₂₀F₃N₂O₇P
Molecular Weight:476.346
Hs Code.:

Synonyms:3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

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Chemical Property of 3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

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Technology Process of 3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

There total 8 articles about 3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582263-10-2
dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

: 1582262-10-9
3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

Guidance literature:: dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate; With palladium 10% on activated carbon; hydrogen; In ethanol; water; for 1h; under 760.051 Torr;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1582262-10-9
3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / toluene; hexane / 0.67 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

3.2: 1 h / 0 °C

4.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 1 h / 760.05 Torr

4.2: 0 - 20 °C

With n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; water; toluene; mineral oil;

Reference yield:

: 1431551-88-0
(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

: 1582262-10-9
3-[5-(4-{(1R,2S)-2-[(difluoroacetyl)amino]-3-fluoro-1-hydroxypropyl}phenyl)pyridin-2-yl]oxetan-3-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

3.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

4.2: 1 h / 0 °C

5.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 1 h / 760.05 Torr

5.2: 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; mineral oil;