dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

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Chemical Name:dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate
CAS No.:1582263-10-2
Molecular Formula:C₃₆H₃₆F₃N₂O₇P
Molecular Weight:696.66
Hs Code.:

Synonyms:dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

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Chemical Property of dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

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Technology Process of dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

There total 7 articles about dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 1582262-85-8
3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-ol

: 1582263-10-2
dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

Guidance literature:: 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1582263-10-2
dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

4.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

5.2: 1 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; mineral oil;

Reference yield:

: 1207758-80-2
3-(5-bromopyridin-2-yl)oxetan-3-ol

: 1582263-10-2
dibenzyl 3-(5-{4-[(4S,5R)-3-(difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyl-1,3-oxazolidin-5-yl]phenyl}pyridin-2-yl)oxetan-3-yl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 2 h / 60 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

2.2: 1 h / 0 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;