N-(2,3,4-trihydroxyphenyl)acetamide

Base Information

Chemical Name:N-(2,3,4-trihydroxyphenyl)acetamide
CAS No.:227026-22-4
Molecular Formula:C₈H₉NO₄
Molecular Weight:183.164
Hs Code.:

Synonyms:N-(2,3,4-trihydroxyphenyl)acetamide

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Chemical Property of N-(2,3,4-trihydroxyphenyl)acetamide

Chemical Property:

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Technology Process of N-(2,3,4-trihydroxyphenyl)acetamide

There total 8 articles about N-(2,3,4-trihydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1618644-89-5
N-(2,3,4-tris(benzyloxy)phenyl)acetamide

: 227026-22-4
N-(2,3,4-trihydroxyphenyl)acetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 25 ℃; under 2325.23 Torr;
DOI:10.1039/c4ob00445k

Reference yield:

: 610-02-6
2,3,4-trihydroxybenzoic acid

: 227026-22-4
N-(2,3,4-trihydroxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; sodium iodide / acetone / Reflux

2.1: potassium hydroxide / methanol / Reflux

2.2: 20 °C / pH 3 - 4

3.1: diphenyl phosphoryl azide; triethylamine / 5 h / 20 - 75 °C / Inert atmosphere

4.1: 75 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 °C / Inert atmosphere

6.1: pyridine / 20 °C

7.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 25 °C / 2325.23 Torr

With pyridine; diphenyl phosphoryl azide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; acetone; 3.1: |Curtius Rearrangement;
DOI:10.1039/c4ob00445k

Reference yield:

: 180206-32-0
2,3,4-tris(benzyloxy)benzoic acid

: 227026-22-4
N-(2,3,4-trihydroxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; triethylamine / 5 h / 20 - 75 °C / Inert atmosphere

2: 75 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 °C / Inert atmosphere

4: pyridine / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 25 °C / 2325.23 Torr

With pyridine; diphenyl phosphoryl azide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; In tetrahydrofuran; methanol; 1: |Curtius Rearrangement;
DOI:10.1039/c4ob00445k