1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate
• CAS No.: 1158971-61-9
• Molecular Formula: C₂₁H₂₅F₂NO₃
• Molecular Weight: 377.431

Synonyms:1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate

Chemical Property of 1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate

Chemical Property:

Purity/Quality:

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Technology Process of 1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate

There total 1 articles about 1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-methyl 2-(((tert-butoxy)carbonyl)amino)butanoate (58561-08-3,112392-65-1,142035-85-6,93267-05-1) + 4-flourophenylmagnesium bromide (352-13-6) → 1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate (1158971-61-9)

Guidance literature:

(S)-methyl 2-(((tert-butoxy)carbonyl)amino)butanoate; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃;

With ammonium chloride; In water;

DOI:10.1021/jm900110t

Reference yield: 93.0%

1,1-dimethylethyl {(1S)-1-[bis(4-fluorophenyl)(hydroxy)methyl]propyl}carbamate (1158971-61-9) → (2S)-2-amino-1,1-bis(4-fluorophenyl)-1-butanol hydrochloride (1158971-66-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1021/jm900110t

upstream raw materials:

(S)-methyl 2-(((tert-butoxy)carbonyl)amino)butanoate

4-flourophenylmagnesium bromide

Downstream raw materials:

(2S)-2-amino-1,1-bis(4-fluorophenyl)-1-butanol hydrochloride

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