N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

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Chemical Name:N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide
CAS No.:1315585-02-4
Molecular Formula:C₂₇H₃₁N₉O₂S
Molecular Weight:545.668
Hs Code.:

Synonyms:N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

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Chemical Property of N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

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Technology Process of N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

There total 9 articles about N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 1315587-58-6
N-(4-(6-(2-bromoacetamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide

: 1315585-02-4
N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃;

Reference yield:

: 1315587-54-2
2-chloro-N-(5-methyl-1H-pyrazol-3-yl)-6-nitropyrrolo[2,1-f][1,2,4]triazin-4-amine

: 1315585-02-4
N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrogen / Raney nickel / tetrahydrofuran; methanol

3: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 120 °C

With hydrogen; potassium carbonate; Raney nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1204245-51-1
ethyl 1-amino-4-nitro-1H-pyrrole-2-carboxylate

: 1315585-02-4
N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonia / methanol / -10 - 80 °C / Sealed tube

2.1: pyridine / 1,4-dioxane / 1 h / Reflux

3.1: triethylamine; trichlorophosphate / Inert atmosphere; Reflux

4.1: potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 2 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

6.1: hydrogen / Raney nickel / tetrahydrofuran; methanol

7.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

8.1: N,N-dimethyl-formamide / 120 °C

With pyridine; ammonia; hydrogen; potassium carbonate; triethylamine; potassium iodide; trichlorophosphate; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;