4-NITROPYRROLE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-NITROPYRROLE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 5930-92-7
• Molecular Formula: C7H8N2O4
• Molecular Weight: 184.152
• Hs Code.: 2933990090
• Mol file: 5930-92-7.mol

Synonyms:Pyrrole-2-carboxylicacid, 4-nitro-, ethyl ester (6CI,7CI,8CI);4-Nitro-1H-pyrrole-2-carboxylic acidethyl ester;4-Nitropyrrol-2-carboxylic acid ethyl ester;4-Nitropyrrole-2-carboxylic acid ethyl ester;Ethyl4-nitro-2-pyrrolecarboxylate;NSC 50357;ethyl 4-nitro-1H-pyrrole-2-carboxylate;

Chemical Property of 4-NITROPYRROLE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 174 °C
• Boiling Point: 347.7 °C at 760 mmHg
• PKA: 12.21±0.50(Predicted)
• Flash Point: 164.1 °C
• PSA: 87.91000
• Density: 1.374 g/cm³
• LogP: 1.62280
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99.5% ^*data from raw suppliers

Ethyl4-nitro-1H-pyrrole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITROPYRROLE-2-CARBOXYLIC ACID ETHYL ESTER

There total 9 articles about 4-NITROPYRROLE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one (53391-50-7) + ethanol (64-17-5) → Ethyl 4-nitropyrrole-2-carboxylate (5930-92-7)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 16h;

Reference yield: 59.0%

glycine ethyl ester hydrochloride (623-33-6) + N-tert-butyl-β-formyl-β-nitroenamine (181294-58-6) → Ethyl 4-nitropyrrole-2-carboxylate (5930-92-7)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 168h;

DOI:10.1021/jo0488513

Reference yield: 48.0%

glycine ethyl ester hydrochloride (623-33-6) + sodium nitromalonaldehyde (34461-00-2) → Ethyl 4-nitropyrrole-2-carboxylate (5930-92-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 50 ℃; for 1h;

DOI:10.1021/jo00244a003

upstream raw materials:

glycine ethyl ester hydrochloride

nitromalondialdehyde sodium salt

sodium nitromalonaldehyde

methyl 3,5-dinitrobenzoate

Downstream raw materials:

ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

4-nitropyrrole-2-carboxylic acid

4-amino-2-ethoxycarbonyl-pyrrole

N-[4-(4-cyanophenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine