2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)anisole

Base Information

• Chemical Name: 2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)anisole
• CAS No.: 142115-46-6
• Molecular Formula: C₁₅H₁₆OS
• Molecular Weight: 244.357
• Mol file: 142115-46-6.mol

Synonyms:2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)anisole;142115-46-6;2-[(E)-2-(4-methoxy-3,5-dimethylphenyl)ethenyl]thiophene;2-([e]-2-(4-methoxy-3,5-dimethYLPHENYL)ethenyl)thiophene;2-[(E)-2-(4-METHOXY-3,5-DIMETHYL-PHENYL)ETHENYL]THIOPHENE

Chemical Property of 2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)anisole

Chemical Property:

• Vapor Pressure: 3.2E-05mmHg at 25°C
• Boiling Point: 365.9°Cat760mmHg
• Flash Point: 175.1°C
• PSA: 37.47000
• Density: 1.117g/cm³
• LogP: 4.54390
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 244.09218630
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1OC)C)C=CC2=CC=CS2
• Isomeric SMILES: CC1=CC(=CC(=C1OC)C)/C=C/C2=CC=CS2

Technology Process of 2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)anisole

There total 3 articles about 2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,6-dimethyl-4-[2-(thien-2-yl)ethenyl]phenol (127035-58-9) + methyl iodide (74-88-4) → 2,6-dimethyl-4-<2-(2-thienyl)ethenyl>anisole (127036-02-6,142115-46-6)

Guidance literature:

With potassium carbonate; In acetone; for 19h; Ambient temperature;

DOI:10.1021/jm00169a010

Reference yield:

Thiophene-2-acetic acid (1918-77-0) → 2,6-dimethyl-4-<2-(2-thienyl)ethenyl>anisole (127036-02-6,142115-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 46.5 percent / piperidine / CH₂Cl₂ / 7 h / 130 °C

2: 60 percent / K₂CO₃ / acetone / 19 h / Ambient temperature

With piperidine; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm00169a010

Reference yield:

4-hydroxy-3,5-dimethylbenzaldehyde (2233-18-3) → 2,6-dimethyl-4-<2-(2-thienyl)ethenyl>anisole (127036-02-6,142115-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 46.5 percent / piperidine / CH₂Cl₂ / 7 h / 130 °C

2: 60 percent / K₂CO₃ / acetone / 19 h / Ambient temperature

With piperidine; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm00169a010

upstream raw materials:

2,6-dimethyl-4-[2-(thien-2-yl)ethenyl]phenol

methyl iodide

Thiophene-2-acetic acid

4-hydroxy-3,5-dimethylbenzaldehyde