(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Base Information

Chemical Name:(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde
CAS No.:768391-78-2
Molecular Formula:C₂₂H₃₀O₃Si
Molecular Weight:370.564
Hs Code.:

Synonyms:(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Suppliers and Price of (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

There total 4 articles about (2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 768391-74-8
(S)-4-Benzyl-3-[(1S,2S,3R)-2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-3-phenyl-propyl]-5,5-dimethyl-oxazolidin-2-one

: 768391-78-2
(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.tet.2004.05.123

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 768391-78-2
(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

2: 99 percent / DIBAL / CH₂Cl₂ / 0.33 h / -78 °C

3: 72 percent / aq. K₂CO₃ / methanol / 0.25 h / 20 °C

With 1H-imidazole; dmap; diisobutylaluminium hydride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.05.123

Reference yield:

: 768391-70-4
(2'S,3'R,4S)-4-benzyl-3-(2'-benzyloxy-3'-(tert-butyldimethylsilanyloxy)-3'-phenylpropionyl)-5,5-dimethyloxazolidin-2-one

: 768391-78-2
(2S,3R)-2-benzyloxy-3-(tert-butyldimethylsilanyloxy)-3-phenyl-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / DIBAL / CH₂Cl₂ / 0.33 h / -78 °C

2: 72 percent / aq. K₂CO₃ / methanol / 0.25 h / 20 °C

With diisobutylaluminium hydride; potassium carbonate; In methanol; dichloromethane;
DOI:10.1016/j.tet.2004.05.123