bis(2-propyl) N⁴-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine

Base Information

• Chemical Name: bis(2-propyl) N⁴-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine
• CAS No.: 148873-52-3
• Molecular Formula: C₄₀H₄₄N₃O₇P
• Molecular Weight: 709.779
• Mol file: 148873-52-3.mol

Synonyms:bis(2-propyl) N⁴-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine

Chemical Property of bis(2-propyl) N⁴-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(2-propyl) N⁴-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine

There total 3 articles about bis(2-propyl) N⁴-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate (35717-98-7) + (S)-N1-[2-hydroxy-3-(triphenylmethoxy)propyl]-N4-benzoylcytosine (132336-34-6) → bis(2-propyl) N4-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine (148873-52-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 72h; Ambient temperature;

DOI:10.1135/cccc19930649

Reference yield:

diisopropyl hydrogenphosphonate (1809-20-7) → bis(2-propyl) N4-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine (148873-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / 100 °C

2: 1.) Et₃N, 4-dimethylaminopyridine, 2.) triethylammonium hydrogen carbonate / 1.) CH₃CN, 24 h, 2.) CH₃CN, 24 h

3: 92 percent / NaH / dimethylformamide / 72 h / Ambient temperature

With dmap; triethylammonium hydrogen Carbonate; sodium hydride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1135/cccc19930649

Reference yield:

diisopropyl hydroxymethylphosphonate (24630-68-0) → bis(2-propyl) N4-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine (148873-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N, 4-dimethylaminopyridine, 2.) triethylammonium hydrogen carbonate / 1.) CH₃CN, 24 h, 2.) CH₃CN, 24 h

2: 92 percent / NaH / dimethylformamide / 72 h / Ambient temperature

With dmap; triethylammonium hydrogen Carbonate; sodium hydride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1135/cccc19930649

upstream raw materials:

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

(S)-N₁-[2-hydroxy-3-(triphenylmethoxy)propyl]-N₄-benzoylcytosine

diisopropyl hydrogenphosphonate

diisopropyl hydroxymethylphosphonate

Downstream raw materials:

N⁴-benzoyl-1-{(S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-5-[(trimethylsilyl)ethynyl]cytosine

1-{(S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-5-ethynylcytosine

N⁴-benzoyl-1-{(S)-2-[(diisopropoxyphosphoryl)methoxy]-3-(triphenylmethoxy)propyl}-5-iodocytosine

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