24630-68-0

Basic information

• Product Name: DIISOPROPYL HYDROXYMETHYLPHOSPHONATE
• Synonyms: DIISOPROPYL HYDROXYMETHYLPHOSPHONATE;di(propan-2-yloxy)phosphorylmethanol
• CAS NO: 24630-68-0
• Molecular Formula: C₇H₁₇O₄P
• Molecular Weight: 196.18
• Mol File: 24630-68-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 261.6±23.0 °C(Predicted)
• Appearance: /
• Density: 1.094±0.06 g/cm3(Predicted)
• PKA: 12.87±0.10(Predicted)
• CAS DataBase Reference: DIISOPROPYL HYDROXYMETHYLPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIISOPROPYL HYDROXYMETHYLPHOSPHONATE(24630-68-0)
• EPA Substance Registry System: DIISOPROPYL HYDROXYMETHYLPHOSPHONATE(24630-68-0)

Safety Data

• Hazardous Substances Data: 24630-68-0(Hazardous Substances Data)

Usage

General Description

Diisopropyl hydroxymethylphosphonate is a phosphonate compound containing two isopropyl groups and a hydroxymethyl group attached to a phosphorus atom. It is commonly used as a flame retardant and plasticizer in various products including textiles, plastics, and adhesives. This chemical is also known for its effectiveness as a pesticide and is used to control a wide range of insect pests. Diisopropyl hydroxymethylphosphonate is known to have low acute toxicity and is not classified as a carcinogen, mutagen, or reproductive toxicant, making it a relatively safe and versatile compound for a variety of industrial applications.

Upstream product

• 50-00-0 formaldehyd 
• 1809-20-7 diisopropyl hydrogenphosphonate 
• 110-71-4 1,2-dimethoxyethane 
• 691-96-3 diisopropyl phosphite 
• 116-17-6 triisopropyl phosphite 
• 927267-66-1 diisopropyl (tributylstannyl)methyl phosphate 
• 26955-63-5 diisopropyl methyl phosphate 

Downstream Products

• 34833-73-3 diisopropyl 3-nitrobenzenesulfonyloxymethylphosphonate 
• 143056-56-8 diisopropyl <<<4-(chloromethyl)benzyl>oxy>methyl>phosphonate 
• 203172-83-2 (diisopropylphosphonyl)methyl 3,5-bis-O-benzoyl-2-deoxy-β-D-erythro-pentofuranoside 
• 203172-82-1 (diisopropylphosphonyl)methyl 3,5-bis-O-benzoyl-2-deoxy-α-D-erythro-pentofuranoside 
• 203172-89-8 3-Trifluoromethyl-benzoic acid (2S,3R,4R,5R)-4-benzoyloxy-5-benzoyloxymethyl-2-(diisopropoxy-phosphorylmethoxy)-tetrahydro-furan-3-yl ester 
• 265322-97-2 (Z)-1-benzoxy-4-[((diisopropylphosphono)methoxy)methoxy]-2-butene 
• 143056-49-9 diisopropyl <<2-(chloromethyl)phenoxy>methyl>phosphonate 
• 143056-48-8 diisopropyl <<2-(hydroxymethyl)phenoxy>methyl>phosphonate 
• 143056-68-2 diisopropyl <<2-<(2-amino-6-chloro-9H-purin-9-yl)methyl>phenoxy>methyl>phosphonate 
• 143056-73-9 diisopropyl <<<4-<(2-amino-6-chloro-9H-purin-9-yl)methyl>benzyl>oxy>methyl>phosphonate 
• 143056-70-6 diisopropyl <<<2-<(2-amino-6-chloro-9H-purin-9-yl)methyl>benzyl>oxy>methyl>phosphonate 
• 143056-69-3 diisopropyl <<<3-<(2-amino-6-chloro-9H-purin-9-yl)methyl>benzyl>oxy>methyl>phosphonate 
• 34833-69-7 diisopropyl benzenesulfonyloxymethylphosphonate 
• 1023289-21-5 diisopropyl (4-nitrobenzenesulfonyloxy)methylphosphonate 

Relevant articles and documents

Chemoenzymatic Synthesis of Racemic and Enantiomerically Pure Phosphaaspartic Acid and Phosphaarginine

Diisopropyl allyloxymethylphosphonate prepared by a one-pot procedure was isomerized to give racemic 1-hydroxy-3-butenylphosphonate with LDA by a [2,3]-sigmatropic rearrangement. Chloroacetylation delivered an ester, which was resolved in a two-phase system by using the lipase from Thermomyces lanuginosus. Racemic and (S)-α-hydroxyphosphonate 6 were converted to (±)- and (R)-phosphaaspartic acid by functional-group manipulation. (±)-, (R)- and (S)-6 were first esterified with 4-nitrobenzenesulfonyl chloride before hydroboration to transform the double bond into a hydroxyethyl group. The hydroxyl group was manipulated to give a guanidinyl group and the 4-nitrobenzenesulfonyloxy to give an amino group. Global deprotection of the α-aminophosphonates yielded the desired phosphaamino acids.

THYROID HORMONE RECEPTOR AGONIST AND USE THEREOF

A thyroid hormone receptor agonist and its use in the treatment of a disease associated thyroid hormone receptor beta are described. The compound can be effective in lowering cholesterol with minimum or no adverse effects on the heart or thyroid hormone axis.

Copper-catalyzed synthesis of α-hydroxy phosphonates from H-phosphonates and alcohols or ethers

Easy PC: α-Hydroxy phosphonates were synthesized by copper/tert-butyl hydroperoxide (TBHP)-catalyzed oxidative addition reactions of H-phosphonates with alcohols or ethers. Diverse α-hydroxy phosphonates were obtained from substituted benzyl alcohols or alkyl alcohols and alkyl ethers in moderate to good yields. Copyright