Technology Process of benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-hydroxycyclohex-3-enecarboxylate
There total 17 articles about benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-hydroxycyclohex-3-enecarboxylate which
guide to synthetic route it.
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synthetic route:
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1449661-89-5
benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-amino-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-hydroxycyclohex-3-enecarboxylate
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1449661-90-8
benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-hydroxycyclohex-3-enecarboxylate
- Guidance literature:
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With
potassium phosphate; potassium iodide;
In
acetonitrile;
at 100 ℃;
for 15.25h;
Inert atmosphere;
Sealed tube;
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672958-04-2
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-isocyanato-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol
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1449661-90-8
benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-hydroxycyclohex-3-enecarboxylate
- Guidance literature:
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Multi-step reaction with 7 steps
1: hydrogenchloride; water / 1,4-dioxane / 15 h / 60 °C / Inert atmosphere
2: sodium hydrogencarbonate / 1,4-dioxane; water / 16 h / 20 °C / Inert atmosphere
3: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C / Inert atmosphere
4: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
6: sodium carbonate monohydrate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 85 °C / Inert atmosphere
7: potassium iodide; potassium phosphate / acetonitrile / 15.25 h / 100 °C / Inert atmosphere; Sealed tube
With
hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); sodium carbonate monohydrate; water; potassium hexamethylsilazane; sodium hydrogencarbonate; pyridinium chlorochromate; trifluoroacetic acid; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
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1449661-90-8
benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-hydroxycyclohex-3-enecarboxylate
- Guidance literature:
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Multi-step reaction with 10 steps
1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane; acetonitrile / 20 °C / Inert atmosphere; Molecular sieve
2: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere
3: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16.66 h / 20 - 102 °C / Inert atmosphere
4: hydrogenchloride; water / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
5: sodium hydrogencarbonate / dichloromethane / Inert atmosphere
6: tetrahydrofuran / 48 h / 20 °C / Inert atmosphere
7: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
8: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
9: sodium carbonate monohydrate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 85 °C / Inert atmosphere
10: potassium iodide; potassium phosphate / acetonitrile / 15.25 h / 100 °C / Inert atmosphere; Sealed tube
With
hydrogenchloride; sodium chlorite; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); tetrapropylammonium perruthennate; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; sodium carbonate monohydrate; diphenyl phosphoryl azide; water; potassium hexamethylsilazane; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; tert-butyl alcohol;