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Betulin

Base Information
  • Chemical Name:Betulin
  • CAS No.:473-98-3
  • Molecular Formula:C30H50O2
  • Molecular Weight:442.726
  • Hs Code.:29181985
  • European Community (EC) Number:207-475-5
  • NSC Number:692218
  • UNII:6W70HN7X7O
  • DSSTox Substance ID:DTXSID101019934
  • Nikkaji Number:J5.959E
  • Wikipedia:Betulin
  • Wikidata:Q419726
  • Metabolomics Workbench ID:28740
  • ChEMBL ID:CHEMBL23236
  • Mol file:473-98-3.mol
Betulin

Synonyms:(+)-betulin;(+)-betulin diacetate;3,28-di-O-acetylbetulin;3,28-diacetoxy-betulin;betulin;betulin diacetate;betuline;betulinic alcohol;betulinol;betulinol biacetate;betulinol diacetate;lup-20(29)-en-3 alpha, 28,30-triol;lup-20(29)-ene-3 beta,28-diol;lup-20(29)-ene-3,28-diol, 3,28-diacetate, (3 beta)-;lup-20(29)-ene-3alpha,28-diol

Suppliers and Price of Betulin
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Betulin
  • 20mg
  • $ 280.00
  • Usbiological
  • Betulin
  • 1g
  • $ 403.00
  • TRC
  • Betulin
  • 1g
  • $ 110.00
  • TCI Chemical
  • Betulinol >97.0%(GC)
  • 100mg
  • $ 66.00
  • Sigma-Aldrich
  • SREBP Processing Inhibitor, Betulin
  • 250mg
  • $ 81.00
  • Sigma-Aldrich
  • Betulin analytical standard
  • 50mg
  • $ 128.00
  • Sigma-Aldrich
  • Betulin ≥98%
  • 1g
  • $ 107.00
  • Sigma-Aldrich
  • Betulin ≥98%
  • 5g
  • $ 155.00
  • Medical Isotopes, Inc.
  • Betulin
  • 1 g
  • $ 190.00
  • Matrix Scientific
  • (1R,3AS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol 95+%
  • 500mg
  • $ 18.00
Total 175 raw suppliers
Chemical Property of Betulin
Chemical Property:
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:4.32E-13mmHg at 25°C 
  • Melting Point:256-257 °C(lit.) 
  • Refractive Index:1.524 
  • Boiling Point:522.275 °C at 760mm Hg 
  • PKA:15.10±0.10(Predicted) 
  • Flash Point:210.873 °C 
  • PSA:40.46000 
  • Density:1.017 g/cm3 
  • LogP:6.99720 
  • Storage Temp.:2-8°C 
  • Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated) 
  • XLogP3:8.3
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:2
  • Exact Mass:442.381080833
  • Heavy Atom Count:32
  • Complexity:786
Purity/Quality:

95%-98% *data from raw suppliers

Betulin *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn, IrritantXi 
  • Hazard Codes:Xn,Xi 
  • Statements: 36/37/38-20/21/22-68/20/21/22-68 
  • Safety Statements: 36/37-36-26 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO
  • Isomeric SMILES:CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO
  • General Description Betulin is a lupane-type triterpenoid compound characterized by the presence of hydroxyl groups at positions 3 and 28, with the chemical structure Lup-20(29)-ene-3β,28-diol. It is found in various plant species, including Betula ermanii and Diospyros species, and is associated with triterpenoid-rich extracts. Known by multiple synonyms such as betulinol, betulol, and betulinic alcohol, it has been studied for its potential medicinal and phytochemical significance.
Technology Process of Betulin

There total 23 articles about Betulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With potassium hydroxide; In ethanol; for 2h; Heating;
Guidance literature:
With montmorillonite K-10; In methanol; at 40 - 50 ℃; for 2h;
DOI:10.1080/00397919908085755
Guidance literature:
With sodium hydroxide; In ethanol; toluene; at 60 ℃; for 3h;
DOI:10.1134/S1070428010100088
Refernces

Chemical evaluation of Betula species in Japan. I. Constituents of Betula ermanii

10.1248/cpb.43.1937

The research focused on the chemical evaluation of Betula species in Japan, specifically the constituents of Betula ermanii. The purpose of the study was to identify and characterize the chemical compounds present in different parts of the tree, including the fresh leaves, outer bark, inner bark, and root bark. The research concluded that the tree contained a variety of dammarane-type triterpenes, lignans, triterpenes, phenolics, and caffeoyl esters. Some of the key chemicals identified were 20(S),24(R)-epoxydammaran-3,11x,25-triol and its derivatives, betulin, betulin 3-caffeate, oleanolic acid, and various lignans such as (+)-lyoniresinol and (-)-lyoniresinol. The study also reported several new compounds, including 2, 3, 4, 6, 19, and 21, which were dammarane-type glycosides isolated for the first time from the leaves of Betula species. This comprehensive analysis of Betula ermanii's chemical constituents contributes to the understanding of its potential medicinal value, building on the known traditional uses of other Betula species in medicine and cosmetics.

Chemical constituents of Diospyros buxifolia, D. tomentosa, D. ferra, D. lotus, Rhus parviflora, Polygonum recumbens, Balanites aegyptiaca and Pyrus pashia

10.1016/S0031-9422(00)97297-2

This research aimed to identify and isolate the chemical constituents of various plant species, including Diospyros buxifolia, D. tomentosa, D. ferra, D. lotus, Balanites aegyptiaca, Rhus parviflora, Polygonum recumbens, and Pyrus pashia. The study involved the extraction and chromatographic separation of compounds from these plants, leading to the identification of various triterpenes, steroids, and other chemical constituents such as friedelin, epi-friedelinol, p-sitosterol, lupeol, betulin, betulinic acid, and maslinic acid, among others. The research concluded with the detailed characterization of these compounds, including their melting points, optical rotations, and spectroscopic data, which contribute to the understanding of the phytochemical profiles of the studied plants and may have implications for their medicinal properties.

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