2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

Base Information

Chemical Name:2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester
CAS No.:889656-31-9
Molecular Formula:C₂₂H₃₆O₃Si
Molecular Weight:376.612
Hs Code.:

Synonyms:2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

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Chemical Property of 2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

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Technology Process of 2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

There total 6 articles about 2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 889656-30-8
2-hydroxymethyl-4-phenylpent-4-enoic acid tert-butyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 889656-31-9
2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/ja058299e

Reference yield:

: 869811-06-3
4-phenylpent-4-enoic acid tert-butyl ester

: 889656-31-9
2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 0.33 h / -78 °C

1.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -78 °C

2.1: 2.32 g / NaBH₄ / methanol / 0.33 h / 0 °C

3.1: 91 percent / imidazole / dimethylformamide / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja058299e

Reference yield:

: C₁₃H₁₁F₃O₃

: 889656-31-9
2-(tert-butyldimethylsilanyloxymethyl)-4-phenylpent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4.32 g / tetrahydrofuran / 12 h / 20 °C

2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 0.33 h / -78 °C

2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -78 °C

3.1: 2.32 g / NaBH₄ / methanol / 0.33 h / 0 °C

4.1: 91 percent / imidazole / dimethylformamide / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja058299e