methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

Base Information

Chemical Name:methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate
CAS No.:1620300-12-0
Molecular Formula:C₁₄H₂₃NO₅
Molecular Weight:285.34
Hs Code.:

Synonyms:methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

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Chemical Property of methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

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Technology Process of methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

There total 1 articles about methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 1620300-12-0
methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 23 ℃; for 16h;
DOI:10.1016/j.tetlet.2014.06.058

Reference yield: 95.0%

: 1620300-12-0
methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

: 368866-33-5
(S)-2-(tert-butoxycarbonylamino)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate; With [(1R,1'R,2R,2'R)-2,2'-bis(1,1-dimethylethyl)-2,2',3,3'-tetrahydro-1,1'-bis-1H-isophosphindole-κP2,κP2'][(1,2,5,6-η)-1,5-cyclooctadiene]rhodium(1)tetrafluoroborate; water; hydrogen; In methanol; for 3h; under 2585.81 Torr;

With lithium hydroxide; In tetrahydrofuran; at 23 ℃; for 7h;
DOI:10.1016/j.tetlet.2014.06.058

Reference yield:

: 1620300-12-0
methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

: 182287-51-0
2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium carbon (20 wt%) / methanol / 3 h / 23 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 23 °C / Inert atmosphere

With palladium carbon (20 wt%); water; hydrogen; lithium hydroxide; In tetrahydrofuran; methanol;