(2S)-2-[(Tert-butoxycarbonyl)amino]-3-tetrahydro-2H-pyran-4-ylpropanoic acid

Base Information

Chemical Name:(2S)-2-[(Tert-butoxycarbonyl)amino]-3-tetrahydro-2H-pyran-4-ylpropanoic acid
CAS No.:368866-33-5
Molecular Formula:C₁₃H₂₃NO₅
Molecular Weight:273.329
Hs Code.:
DSSTox Substance ID:DTXSID101133675

Synonyms:368866-33-5;(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(oxan-4-yl)propanoic acid;(2S)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-TETRAHYDRO-2H-PYRAN-4-YLPROPANOIC ACID;(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(oxan-4-yl)propanoic acid;(S)-2-((tert-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid;(2S)-2-([(tert-Butoxy)carbonyl]amino)-3-(oxan-4-yl)propanoic acid;(2s)-2-(((tert-butoxy)carbonyl)amino)-3-(oxan-4-yl)propanoic acid;SCHEMBL16774;NKYZORHKIYSSEL-JTQLQIEISA-N;DTXSID101133675;AMY35721;MFCD18252725;AKOS026739578;AS-43449;CS-0053446;EN300-1589855;(2S)-2-(Boc-amino)-3-(oxan-4-yl)propanoic acid;N-(tert-butoxycarbonyl)-3-(tetrahydro-2H-pyran-4-yl)-alanine;N-(tert-butoxycarbonyl)-3-(tetrahydro-2H-pyran-4-yl)-L-alanine;(alphaS)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]tetrahydro-2H-pyran-4-propanoic acid;(S)-2-((t-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid;(S)-2-((tert-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid

Suppliers and Price of (2S)-2-[(Tert-butoxycarbonyl)amino]-3-tetrahydro-2H-pyran-4-ylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-2-((tert-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid 95+%
1g
$ 883.00

ChemScene
(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(oxan-4-yl)propanoicacid
250mg
$ 360.00

ChemScene
(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(oxan-4-yl)propanoicacid
100mg
$ 216.00

ChemScene
(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(oxan-4-yl)propanoicacid
1g
$ 1050.00

Chemenu
(S)-2-((tert-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid 95%
1g
$ 1066.00

American Custom Chemicals Corporation
(2S)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-TETRAHYDRO-2H-PYRAN-4-YLPROPANOIC ACID 95.00%
5MG
$ 505.07

Activate Scientific
(2S)-2-(Boc-amino)-3-(oxan-4-yl)propanoic acid 97% ee
100 mg
$ 193.00

Activate Scientific
(2S)-2-(Boc-amino)-3-(oxan-4-yl)propanoic acid 97% ee
250 mg
$ 394.00

Activate Scientific
(2S)-2-(Boc-amino)-3-(oxan-4-yl)propanoic acid 97% ee
1 g
$ 969.00

ACHEMBLOCK
(2S)-2-{[(tert-Butoxy)carbonyl]amino}-3-(oxan-4-yl)propanoicacid 97%
1G
$ 910.00

Total 10 raw suppliers

Chemical Property of (2S)-2-[(Tert-butoxycarbonyl)amino]-3-tetrahydro-2H-pyran-4-ylpropanoic acid

Chemical Property:

Boiling Point:434.8±20.0 °C(Predicted)
Density:1.131±0.06 g/cm3(Predicted)
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:273.15762283
Heavy Atom Count:19
Complexity:318

Purity/Quality:

99%, ^*data from raw suppliers

(S)-2-((tert-Butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1CCOCC1)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1CCOCC1)C(=O)O

Technology Process of (2S)-2-[(Tert-butoxycarbonyl)amino]-3-tetrahydro-2H-pyran-4-ylpropanoic acid

There total 5 articles about (2S)-2-[(Tert-butoxycarbonyl)amino]-3-tetrahydro-2H-pyran-4-ylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1620300-12-0
methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate

: 368866-33-5
(S)-2-(tert-butoxycarbonylamino)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: methyl (Z)-2-((tert-butoxycarbonyl)amino)-3-(tetrahydro-2H-pyran-4-yl)acrylate; With [(1R,1'R,2R,2'R)-2,2'-bis(1,1-dimethylethyl)-2,2',3,3'-tetrahydro-1,1'-bis-1H-isophosphindole-κP2,κP2'][(1,2,5,6-η)-1,5-cyclooctadiene]rhodium(1)tetrafluoroborate; water; hydrogen; In methanol; for 3h; under 2585.81 Torr;

With lithium hydroxide; In tetrahydrofuran; at 23 ℃; for 7h;
DOI:10.1016/j.tetlet.2014.06.058

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 368866-33-5
(S)-2-(tert-butoxycarbonylamino)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; (Rc,Sp)-Duanphos / methanol / 3 h / 20 °C / 3345.86 Torr / Inert atmosphere

3: lithium hydroxide; water / tetrahydrofuran; water / 20 °C / pH 3 / Inert atmosphere

With (Rc,Sp)-Duanphos; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm4016735