(3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

Base Information

Chemical Name:(3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole
CAS No.:880633-78-3
Molecular Formula:C₃₁H₃₆O₅
Molecular Weight:488.624
Hs Code.:

Synonyms:(3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

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Chemical Property of (3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

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Technology Process of (3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

There total 3 articles about (3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-39-0
benzyl bromide

: 101917-46-8
(3aS,4R,6R,7aR)-6-Hydroxymethyl-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-4,6-diol

: 880633-78-3
(3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

Guidance literature:: (3aS,4R,6R,7aR)-6-Hydroxymethyl-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-4,6-diol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.16667h;

benzyl bromide; In tetrahydrofuran; at 20 - 70 ℃; for 47h;
DOI:10.3987/com-05-s(k)56

Reference yield:

: 32384-42-2
(1S,3R,4S,5R)-3,4-O-isopropylidene-1,5-quinic lactone

: 880633-78-3
(3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 6.06 g / sodium borohydride / methanol / 2.5 h / 0 °C

2.1: NaH / tetrahydrofuran / 1.17 h / 20 °C

2.2: 91 percent / tetrahydrofuran / 47 h / 20 - 70 °C

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.3987/com-05-s(k)56

Reference yield:

: 77-95-2
D-(-)-quinic acid

: 880633-78-3
(3aS,4R,6R,7aR)-4,6-bis(benzyloxy)-6-(benzyloxymethyl)-hexahydro-2,2-dimethylbenzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / (+)-CSA / benzene

2.1: 6.06 g / sodium borohydride / methanol / 2.5 h / 0 °C

3.1: NaH / tetrahydrofuran / 1.17 h / 20 °C

3.2: 91 percent / tetrahydrofuran / 47 h / 20 - 70 °C

With sodium tetrahydroborate; (1S)-10-camphorsulfonic acid; sodium hydride; In tetrahydrofuran; methanol; benzene;
DOI:10.3987/com-05-s(k)56