tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

Base Information

Chemical Name:tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester
CAS No.:219832-77-6
Molecular Formula:C₂₄H₄₂N₄O₈
Molecular Weight:514.619
Hs Code.:

Synonyms:tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

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Chemical Property of tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

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Technology Process of tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

There total 1 articles about tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 219832-77-6
tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / DBU / CH₂Cl₂ / 24 h

2: H₂ / Pd/C / methanol / 2.5 h

3: DIEA / CH₂Cl₂ / 24 h

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00613-1

Reference yield:

: 219832-77-6
tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

: 219832-87-8
(6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-(1-carbamimidoyl-piperidin-4-yl)-2-oxo-2-thiazol-2-yl-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH / H₂O; methanol / 2 h

2: BOP, DIEA / CH₂Cl₂ / 4 h

3: 80 percent / n-BuLi, TMEDA / tetrahydrofuran / 3 h / -78 °C

4: 100 percent / 4N aq. HCl / dioxane / 3 h

5: BOP, DIEA / acetonitrile / 2 h

With hydrogenchloride; lithium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0960-894X(98)00613-1

Reference yield:

: 219832-77-6
tert-Butoxycarbonylamino-(1-{tert-butoxycarbonylamino-[(Z)-tert-butoxycarbonylimino]-methyl}-piperidin-4-yl)-acetic acid methyl ester

: 219832-87-8
(6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(R)-1-(1-carbamimidoyl-piperidin-4-yl)-2-oxo-2-thiazol-2-yl-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH / H₂O; methanol / 2 h

2: BOP, DIEA / CH₂Cl₂ / 4 h

3: 80 percent / n-BuLi, TMEDA / tetrahydrofuran / 3 h / -78 °C

4: 100 percent / 4N aq. HCl / dioxane / 3 h

5: BOP, DIEA / acetonitrile / 2 h

With hydrogenchloride; lithium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0960-894X(98)00613-1