1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

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Chemical Name:1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one
CAS No.:1323074-06-1
Molecular Formula:C₂₄H₂₅N₅O₃
Molecular Weight:431.494
Hs Code.:

Synonyms:1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

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Chemical Property of 1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

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Technology Process of 1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

There total 4 articles about 1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 123-75-1
pyrrolidine

: 62348-18-9
3-methyl-1,2-oxazole-4-carboxylic acid chloride

: 1323076-87-4
10a-(4-bromophenyl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

: 1323074-05-0
1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-phenyl-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

: 1323074-06-1
1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Guidance literature:: pyrrolidine; 10a-(4-bromophenyl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one; With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 150 - 160 ℃; for 0.583333h; Microwave irradiation;

3-methyl-1,2-oxazole-4-carboxylic acid chloride; With pyridine; at 20 ℃; Cooling with ice;

Reference yield:

: 17153-20-7
3-methyl isoxazole-4-carboxylic acid

: 1323074-06-1
1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.58 h / 150 - 160 °C / Microwave irradiation

2.2: 20 °C / Cooling with ice

With oxalyl dichloride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; In dichloromethane; toluene;

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 1323074-06-1
1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 2.25 h / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 17 h / 20 °C

2.2: pH 1

3.1: xylenes / 1 h / Reflux

4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.58 h / 150 - 160 °C / Microwave irradiation

4.2: 20 °C / Cooling with ice

With lithium hydroxide monohydrate; potassium tert-butylate; water; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; xylenes;