3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine

Base Information

• Chemical Name: 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine
• CAS No.: 1354571-20-2
• Molecular Formula: C₂₁H₁₇Cl₂N₃O₂
• Molecular Weight: 414.291
• Mol file: 1354571-20-2.mol

Synonyms:3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine

Chemical Property of 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine

There total 4 articles about 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-bis(3',5'-dimethyl-1'-pyrazolylcarbonyl)-2,6-dimethylpyridine (1354571-13-3) + 4-chloro-aniline (106-47-8) → 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine (1354571-20-2)

Guidance literature:

With acetic acid; In toluene; for 1h; Reflux;

DOI:10.1002/cjoc.201180367

Reference yield:

2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester (1149-24-2) → 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine (1354571-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 6 h / Reflux; Neat (no solvent)

2: toluene-4-sulfonic acid / chloroform / 2 h / Reflux

3: acetic acid / toluene / 1 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In chloroform; toluene;

DOI:10.1002/cjoc.201180367

Reference yield:

diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1149-23-1) → 3,5-bis[N-(4-chlorophenyl)carbamoyl]-2,6-dimethylpyridine (1354571-20-2)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; sodium nitrite / ethanol; water / 1 h / Reflux

2: hydrazine hydrate / 6 h / Reflux; Neat (no solvent)

3: toluene-4-sulfonic acid / chloroform / 2 h / Reflux

4: acetic acid / toluene / 1 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; sodium nitrite; In ethanol; chloroform; water; toluene;

DOI:10.1002/cjoc.201180367

upstream raw materials:

3,5-bis(3',5'-dimethyl-1'-pyrazolylcarbonyl)-2,6-dimethylpyridine

4-chloro-aniline

diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester

Refernces