(4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:(4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:926035-13-4
Molecular Formula:C₁₉H₂₂ClNO₅S
Molecular Weight:411.906
Hs Code.:

Synonyms:(4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

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Chemical Property of (4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

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Technology Process of (4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 5 articles about (4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 926035-11-2
(4R,5R)-4-acetoxy-7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 108-05-4,9003-20-7
vinyl acetate

: 926035-13-4
(4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: (4R,5R)-4-acetoxy-7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine; With sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;

vinyl acetate; With Lipase QLM; In acetonitrile; at 65 ℃; for 1h;

With sodium hydroxide; In ethanol; at 20 ℃; for 0.5h; Further stages.;
DOI:10.3987/COM-06-S(O)42

Reference yield: 98.0%

: 926035-11-2
(4R,5R)-4-acetoxy-7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 926035-13-4
(4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;
DOI:10.3987/COM-06-S(O)42

Reference yield:

: trans-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 926035-13-4
(4R,5R)-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / isopropyl ether; Lipase QLM / 24 h / 65 °C

2: 98 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

With sodium hydroxide; Lipase QLM; di-isopropyl ether; In ethanol;
DOI:10.3987/COM-06-S(O)42