(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

Base Information

Chemical Name:(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol
CAS No.:952652-09-4
Molecular Formula:C₂₈H₃₄O₃Si
Molecular Weight:446.662
Hs Code.:

Synonyms:(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

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Chemical Property of (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

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Technology Process of (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

There total 12 articles about (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 952651-73-9
(1'R)-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]acetaldehyde

: 590-15-8
trans-2-propenyl bromide

: 952652-09-4
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

Guidance literature:: trans-2-propenyl bromide; With lithium; In diethyl ether; at 0 ℃; for 2h;

(1'R)-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]acetaldehyde; In diethyl ether; at -78 - -50 ℃; for 1h; Further stages.;
DOI:10.1021/ol071382h

Reference yield:

: 952652-05-0
(-)-(R)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

: 952652-09-4
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Br₂ / CH₂Cl₂ / -78 °C

1.2: 91 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

2.1: 95 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

3.1: lithium / diethyl ether / 2 h / 0 °C

3.2: 88 percent / diethyl ether / 1 h / -78 - -50 °C

With oxalyl dichloride; bromine; lithium; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol071382h

Reference yield:

: 952652-07-2
(1'R)-2-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]ethanol

: 952652-09-4
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

2.1: lithium / diethyl ether / 2 h / 0 °C

2.2: 88 percent / diethyl ether / 1 h / -78 - -50 °C

With oxalyl dichloride; lithium; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 1.1: Swern oxidation;
DOI:10.1021/ol071382h