(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

Base Information

Chemical Name:(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one
CAS No.:952651-76-2
Molecular Formula:C₂₈H₃₂O₃Si
Molecular Weight:444.646
Hs Code.:

Synonyms:(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

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Chemical Property of (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

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Technology Process of (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

There total 13 articles about (1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 952652-09-4
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-ol

: 952651-76-2
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

Guidance literature:: With phthalic acid dimethyl ester; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol071382h

Reference yield:

: 952652-05-0
(-)-(R)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

: 952651-76-2
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: Br₂ / CH₂Cl₂ / -78 °C

1.2: 91 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

2.1: 95 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

3.1: lithium / diethyl ether / 2 h / 0 °C

3.2: 88 percent / diethyl ether / 1 h / -78 - -50 °C

4.1: 96 percent / DMP / CH₂Cl₂ / 0 - 20 °C

With oxalyl dichloride; phthalic acid dimethyl ester; bromine; lithium; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol071382h

Reference yield:

: 952651-73-9
(1'R)-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]acetaldehyde

: 952651-76-2
(1'R)-1-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]pent-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium / diethyl ether / 2 h / 0 °C

1.2: 88 percent / diethyl ether / 1 h / -78 - -50 °C

2.1: 96 percent / DMP / CH₂Cl₂ / 0 - 20 °C

With phthalic acid dimethyl ester; lithium; In diethyl ether; dichloromethane;
DOI:10.1021/ol071382h