1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene

Base Information

• Chemical Name: 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene
• CAS No.: 1332499-17-8
• Molecular Formula: C₄₈H₇₈N₁₀O₁₀P₂
• Molecular Weight: 1017.16
• Mol file: 1332499-17-8.mol

Synonyms:1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene

Chemical Property of 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene

There total 12 articles about 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C58H94N10O14P2 (1356826-60-2) → 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene (1332499-17-8)

Guidance literature:

With trifluoroacetic acid; In 1,4-dioxane; water; for 48h;

DOI:10.1039/c1ob05384a

Reference yield:

methyl (6-azidohex-1-yl) [(3R,4R,5S)-4-acetamido-5-(1,1-dimethylethyloxycarbonylamino)-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate] (1332499-11-2) → 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene (1332499-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / toluene / 48 h / 80 °C / Inert atmosphere

2: sodium iodide / acetone / Reflux; Inert atmosphere

3: trifluoroacetic acid / 1,4-dioxane; water / 48 h

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; In 1,4-dioxane; water; acetone; toluene;

DOI:10.1039/c1ob05384a

Reference yield:

C6H15N*C19H35N2O7P → 1,4-bis[1-(hex-1'-yl [(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonic acid])-1H-1,2,3-triazol-4-yl]-benzene (1332499-17-8)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 1 h / Inert atmosphere

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / toluene / 48 h / 80 °C / Inert atmosphere

3: sodium iodide / acetone / Reflux; Inert atmosphere

4: trifluoroacetic acid / 1,4-dioxane; water / 48 h

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; In 1,4-dioxane; water; acetone; toluene; acetonitrile;

DOI:10.1039/c1ob05384a

upstream raw materials:

methyl (6-azidohex-1-yl) [(3R,4R,5S)-4-acetamido-5-(1,1-dimethylethyloxycarbonylamino)-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate]

1,4-bis[1-(hex-1'-yl methyl [(3R,4R,5S)-4-acetamido-5-(1,1dimethylethyloxycarbonylamino)-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate])-1H-1,2,3-triazol-4-yl]-benzene

C₅₈H₉₄N₁₀O₁₄P₂

ammonium [methyl (3R,4R,5S)-4-acetamido-5-(1,1-dimethylethyloxycarbonylamino)-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate]