3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester

Base Information

• Chemical Name: 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester
• CAS No.: 1027085-82-0
• Molecular Formula: C₁₃H₁₄F₂O₂
• Molecular Weight: 240.25
• Mol file: 1027085-82-0.mol

Synonyms:3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester

Chemical Property of 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester

There total 3 articles about 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1-bromoethyl)-1,2-difluorobenzene (150881-71-3) → 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester (1027085-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) EtONa / 1.) EtOH, 0 deg C, 15 min, 2.) EtOH, 40 deg C, overnight

2: 94 percent / KOH / ethanol / 0 - 20 °C

3: Et₂NH / H₂O / 48 h / Ambient temperature

With potassium hydroxide; sodium ethanolate; diethylamine; In ethanol; water;

DOI:10.1021/jm00034a005

Reference yield:

2-[1-(3,4-Difluoro-phenyl)-ethyl]-malonic acid diethyl ester (155943-49-0) → 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester (1027085-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / KOH / ethanol / 0 - 20 °C

2: Et₂NH / H₂O / 48 h / Ambient temperature

With potassium hydroxide; diethylamine; In ethanol; water;

DOI:10.1021/jm00034a005

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-[1-(3,4-Difluoro-phenyl)-ethyl]-malonic acid monoethyl ester → 3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid ethyl ester (1027085-82-0)

Guidance literature:

With diethylamine; In water; for 48h; Ambient temperature;

DOI:10.1021/jm00034a005

upstream raw materials:

formaldehyd

4-(1-bromoethyl)-1,2-difluorobenzene

2-[1-(3,4-Difluoro-phenyl)-ethyl]-malonic acid diethyl ester

Downstream raw materials:

(S)-2-[2-Acetylsulfanylmethyl-3-(3,4-difluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

2-Acetylthiomethyl-3-[(3,4-difluoro)phenyl]butanoic Acid

3-(3,4-Difluoro-phenyl)-2-methylene-butyric acid